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Colchicine may cause severe bone marrow depressionagranulocytosisaplastic anaemiathrombocytopeniaThe change in blood counts may be gradual or very suddenAplastic anaemia in particular has a high mortality ratePeriodic checks of the blood picture are essential.

The concomitant use of Best price on prevacid colchicine capsules and CYP3A4 inhibitorse.gclarithromycinketoconazolegrapefruit juiceerythromycinverapamiletcshould be avoided due to the potential for serious and life-threatening toxicitySee WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY

The magnitude of interactions with strong and moderate CYP3A4 inhibitors as well as with P-gp inhibitors from performed in vivo studies is summarised in the table below:

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monitor cyclosporine concentration and renal function if colchicine is initiated, discontinued, or dosage altered; adjust cyclosporine dosage accordingly 159 161 162.