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Blacktarry stools bleeding gums bloating or swelling of the facearmshandslower legsor feet blood in the urine or stools confusion cough or hoarseness crying delusions dementia depersonalization diarrhea difficult or labored breathing dysphoria euphoria fever or chills general feeling of discomfort or illness headache joint pain loss of appetite lower back or side pain mental depression muscle aches and pains nausea nervousness painful or difficult urination paranoia pinpoint red spots on the skin quick to react or overreact emotionally rapid weight gain rapidly changing moods runny nose shakiness in the legsarmshandsor feet shivering sleepiness or unusual drowsiness sore throat sweating tightness in the chest tingling of the hands or feet trembling or shaking of the hands or feet trouble sleeping unusual bleeding or bruising unusual tiredness or weakness unusual weight gain or loss vomiting.

Tell your healthcare provider about all the medicines you takeincluding prescription and non-prescription medicinesvitaminsherbal supplements.

Many drugs can interact with divalproex sodiumThis includes prescription and over-the-counter medicinesvitaminsand herbal productsNot all possible interactions are listed hereTell your doctor about all your current medicines and any medicine you start or stop using.

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spina bifida from depakote is the most common birth defect associated with the drug.