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Clinical trial and epidemiological data suggest that use of some NSAIDsparticularly at high doses and in long term treatmentmay be associated with a small increased risk of arterial thrombotic eventsfor example myocardial infarction or strokeThere are insufficient data to exclude such a risk for Lodine.

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however, gen-etodolac should be used with caution in such patients because, as with other nsaids, it may further decrease renal function in some patients.