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In parallel design studies involving 244 haemodialysis patients with treatment duration of up to 54 weeks and 97 peritoneal dialysis patients with treatment duration of 12 weeks were conducted.

As data on the chronic use of sevelamer for over one year are not yet availablepotential absorption and accumulation of sevelamer during long-term chronic treatment cannot be totally excludedsee section 5.2

Dysphagia and esophageal tablet retention reportedin some cases requiring hospitalization and interventionconsider sevelamer oral suspension in patients with history of swallowing disorders.

BMay be acceptableEither animal studies show no risk but human studies not available or animal studies showed minor risks and human Roxithromycin generic studies done and showed no risk.

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