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Triptanssuch as rizatriptanMaxaltor almotriptanAxertAntinausea medicinessuch as chlorpromazineThorazinepromethazinePhenerganor prochlorperazineCompazineNon-steroidal anti-inflammatory drugsNSAIDssuch as acetaminophennaproxen sodiumaspirin or ibuprofen.

The development of a potentially life-threatening serotonin syndrome may occur with triptansincluding rizatriptan treatmentparticularly during combined use with SSRIs or SNRIsIf concomitant treatment with rizatriptan and an SSRIe.gfluoxetineparoxetinesertralinefluvoxaminecitalopramescitalopramor SNRIe.gvenlafaxineduloxetineis clinically warrantedcareful observation of the patient is advisedparticularly during treatment initiation and dose increases or with addition of another serotonergic medicationSerotonin syndrome symptoms may include mental status changese.gagitationhallucinationsand comaautonomic instabilitye.gtachycardialabile blood pressureand hyperthermianeuromuscular aberrationse.ghyperreflexiaincoordinationand/or gastrointestinal symptomse.gnauseavomitingand diarrhoea

RIZACT Tablets are not intended for the prophylactic therapy of migraine or for use in the management of haemiplegic or basilar migraineSafety and effectiveness of RIZACT Tablets have not been established for cluster headachewhich is present in an olderpredominantly male population.

In patients receiving propranololthe 5mg dose of RIZACT Tablets should be usedup to a maximum of three doses in any 24-hour period.

Cases of life-threatening serotonin syndrome have been reported during combined use of selective serotonin reuptake inhibitorsSSRIsor serotonin norepinephrine reuptake inhibitorsSNRIsand triptansThere have been reports describing patients with symptoms compatible with serotonin syndromeincluding altered mental statusautonomic instability and neuromuscular abnormalitiesfollowing the use of SSRIs or serotonin norepinephrine reuptake inhibitorsSNRIsand triptans.

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rizact 5mg tablets contains generic rizatriptan as the active moiety in its oral formulation.