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Thereforethe tablet or capsule should not be substituted for the chewable tablets or suspension in the treatment of otitis mediasee Clinical Pharmacology12.3

Increased prothrombin timewith or without clinical bleedinghas been reported when cefixime is administered concomitantly.

Safety and effectiveness of cefixime in children aged less than six months old have not been establishedThe incidence of gastrointestinal adverse reactionsincluding diarrhea and loose stoolsin the pediatric patients receiving the suspensionwas comparable to the incidence seen in adult patients receiving tablets.

Cephalosporinsincluding Supraxmay be associated with a fall in prothrombin activityThose at risk include patients with renal or hepatic impairmentor poor nutritional stateas well as patients receiving a protracted course of antimicrobial therapyand patients previously stabilized on anticoagulant therapyProthrombin time should be monitored in patients at Best price on methotrexate risk and exogenous vitamin K administered as indicated.

Elevated carbamazepine levels have been reported in postmarketing experience when cefixime is administered concomitantlyDrug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.

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