While some of the side effects of imuran azathioprine , cytoxan cyclophosphamide and other immunosuppressive and cytotoxic drugs are noted above, they are generally reversible by either reducing the dosage or stopping the medication.

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The immunosuppressive activity of Imuran could result in an atypical and potentially deleterious response to live vaccines and so the administration of live vaccines to patients receiving Imuran therapy is contra-indicated on theoretical grounds.

The dose of IMURAN required to prevent rejection and minimize toxicity will vary with individual patientsthis necessitates careful managementThe initial dose is usually 3 to 5 mg/kg dailybeginning at the time of transplantIMURAN is usually given as a single daily dose on the day ofand in a minority of cases 1 to 3 days beforetransplantationDose reduction to maintenance levels of 1 to 3 mg/kg daily is usually possibleThe dose of IMURAN should not be increased to toxic levels because of threatened rejectionDiscontinuation may be necessary for severe hematologic or other toxicityeven if rejection of the homograft may be a consequence of drug withdrawal.

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Chromosomal abnormalities have been demonstrated in both male and female patients treated with ImuranIt is difficult to assess the role of Imuran in the development of these abnormalities.

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these imuran may increase your risk of developing a tumor or other toxicity, even if rejection of transplanted people take imuran any more to this amniocentesis.

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