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Serum follicle stimulating hormoneFSHand estradiol levels have not been shown to be useful in the management of moderate to severe symptoms of vulvar and vaginal atrophy.

Use of estrogen-aloneor in combination with a progestinshould be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual womanPostmenopausal women should be re-evaluated periodically as clinically appropriate to determine if treatment is still necessary.

The following adverse reactions have been identified during post-approval use of PREMARIN Vaginal CreamBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

If pregnancy occurs during medication with Premarin treatment should be withdrawn immediatelyThe results of most epidemiological studies to date relevant to inadvertent foetal exposure to estrogens indicate no teratogenic or foetotoxic effects.

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